abstract：OBJECTIVE:The purpose of this study was to evaluate whether the extent of epicardial adipose tissue (EAT) thickness or the presence of descending thoracic aortic calcification on multi-detector CT (MDCT) can predict the presence of significant coronary artery stenosis in patients with negative coronary artery calcium (...

journal_title：Atherosclerosis

authors： Lee HY,Song IS,Yoo SM,Rho JY,Moon JY,White CS

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression. METHODS AND RESULTS:We performed studies in peritoneal macrophages (MPM) from C57BL/6 control mice, or fr...

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Aviram M

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. METHODS:Patients with clinically manifest vascular disease or diabetes (n=5447) from the SMART study...

journal_title：Atherosclerosis

authors： Beulens JW,Algra A,Soedamah-Muthu SS,Visseren FL,Grobbee DE,van der Graaf Y,SMART Study Group.

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Sarcopenia of legs is an important cause of physical dysfunctions, frailty and dependence. Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which i...

journal_title：Atherosclerosis

authors： Ochi M,Kohara K,Tabara Y,Kido T,Uetani E,Ochi N,Igase M,Miki T

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to investigate the effects of one-year treatment with exenatide or Insulin Glargine, followed by a 5-week off-drug period, on postprandial lipidaemia, glycaemia and measures of oxidative stress. METHODS:Sixty-nine metformin-treated patients with type 2 diabetes were ran...

journal_title：Atherosclerosis

authors： Bunck MC,Cornér A,Eliasson B,Heine RJ,Shaginian RM,Wu Y,Yan P,Smith U,Yki-Järvinen H,Diamant M,Taskinen MR

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Although stiffness of central arteries is more preferentially associated with coronary artery disease (CAD) than that of peripheral arteries, less is known for cerebrovascular disease (CVD) and peripheral artery disease (PAD). We measured pulse wave velocity (PWV) in four arterial segments, and examined the ...

journal_title：Atherosclerosis

authors： Tsuchikura S,Shoji T,Kimoto E,Shinohara K,Hatsuda S,Koyama H,Emoto M,Nishizawa Y

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:This study examined whether combined ultrasound assessment of plaque size and echolucency in the carotid artery had an additive effect for predicting coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of either plaque size or echolucency of carotid artery provides prognosti...

journal_title：Atherosclerosis

authors： Hirano M,Nakamura T,Kitta Y,Sano K,Kodama Y,Kobayashi T,Fujioka D,Saito Y,Yano T,Watanabe K,Watanabe Y,Kawabata K,Obata JE,Kugiyama K

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To assess the effect on oxidative damage of the administration of a Mediterranean diet (MD) compared with an Occidental diet (OD), in young adult volunteers, with or without the concomitant intake of red wine. DESIGN:Forty-two omnivorous male students 20-27 years old were given either diet for 3 months. Duri...

journal_title：Atherosclerosis

authors： Urquiaga I,Strobel P,Perez D,Martinez C,Cuevas A,Castillo O,Marshall G,Rozowski J,Leighton F

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

journal_title：Atherosclerosis

authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:HIV+ patients are at increased risk of cardiovascular disease (CVD). Inflammation plays a role in adults, but has not yet been assessed in HIV+ children. We compared proinflammatory cytokines and adhesion molecules in HIV+ children versus healthy controls, and assessed their relationship to carotid intima-me...

journal_title：Atherosclerosis

authors： Ross AC,O'Riordan MA,Storer N,Dogra V,McComsey GA

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:It is unclear whether individuals experience specific patterns of morbidity prior to premature death from cardiovascular disease (CVD). METHODS:We examined morbidity levels in the 6 years leading up to death from CVD in 37,397 men and 113,198 women under 65 years of age from the Finnish Public Sector study,...

journal_title：Atherosclerosis

authors： Singh-Manoux A,Kivimäki M,Sjösten N,Ferrie JE,Nabi H,Pentti J,Virtanen M,Oksanen T,Vahtera J

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Adipocyte fatty acid-binding protein (A-FABP) has been shown to have an effect on insulin resistance, lipid metabolism, and atherosclerosis in animals. We therefore investigated the association between the serum A-FABP level and coronary atherosclerosis. METHODS:One hundred twenty-five consecutive patients ...

journal_title：Atherosclerosis

authors： Miyoshi T,Onoue G,Hirohata A,Hirohata S,Usui S,Hina K,Kawamura H,Doi M,Kusano KF,Kusachi S,Ninomiya Y

更新日期：2010-07-01 00:00:00

abstract：:Inflammation plays a critical role in the development of atherosclerosis and TNF-alpha, a major inflammatory cytokine, induces inflammatory responses by enhancing the expression of adhesion molecules and the secretion of inflammatory mediators. Indirubin is an active compound of Polygonum tinctorium Lour (P. tinctoriu...

journal_title：Atherosclerosis

authors： Kim EJ,Park WH,Ahn SG,Yoon JH,Kim SW,Kim SA

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS:We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as s...

journal_title：Atherosclerosis

authors： Mahabadi AA,Reinsch N,Lehmann N,Altenbernd J,Kälsch H,Seibel RM,Erbel R,Möhlenkamp S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its associa...

journal_title：Atherosclerosis

authors： Aboyans V,Kamineni A,Allison MA,McDermott MM,Crouse JR,Ni H,Szklo M,Criqui MH

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To investigate associations between blood low-density lipoprotein cholesterol (LDL-C) levels and the prevalence of acquired color vision impairment (ACVI) in middle-aged Japanese men. METHODS:Participants in this cross-sectional study underwent color vision testing, ophthalmic examination, a standardized int...

journal_title：Atherosclerosis

authors： Shoji T,Sakurai Y,Sato H,Chihara E,Ishida M,Omae K

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Markers of non-specific inflammation, such as C-reactive protein (CRP) or leukocyte count are increased in end-stage renal disease patients. Recent studies have shown positive associations between inflammatory markers and cardiovascular mortality in kidney transplant recipients, but these analyses had been l...

journal_title：Atherosclerosis

authors： Krüger B,Walberer A,Debler J,Böger CA,Farkas S,Reinhold SW,Obed A,Schlitt HJ,Fischereder M,Banas B,Krämer BK

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression. METHODS AND RESULTS:We used peritoneal macrophages (MPM) from the 6-DS KO mice that were fed a diet without or with AA. Macrophage cholesterol biosynthesis rate and HMGCoA-reductase mRNA level...

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Roqueta-Rivera M,Nakamura MT,Aviram M

更新日期：2010-06-01 00:00:00

abstract：:Measurement of coronary artery calcium score (CACS) by electron beam tomography has been shown to a powerful predictor of coronary heart disease events in asymptomatic non-diabetic subjects. In type 2 diabetes, measurement of CACS was found to be a powerful predictor of cardiovascular events which could enhance predic...

journal_title：Atherosclerosis

authors： Elkeles RS

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Perivascular fat through the secretion of paracrine and pro-inflammatory mediators may play a role in obesity-mediated vascular disease. We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification. METHODS:In p...

journal_title：Atherosclerosis

authors： Lehman SJ,Massaro JM,Schlett CL,O'Donnell CJ,Hoffmann U,Fox CS

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To examine the longitudinal association between toenail selenium levels and subclinical atherosclerosis over an 18-year period. METHODS:Toenail selenium concentrations were examined among 3112 Americans age 20-32 years in 1987 and measured by instrumental neutron-activation analysis. Subclinical atheroscler...

journal_title：Atherosclerosis

authors： Xun P,Liu K,Morris JS,Daviglus ML,He K

更新日期：2010-06-01 00:00:00

abstract：:Leukotriene B(4) (LTB(4)) is a pro-inflammatory lipid mediator generated by the enzymes 5-lipoxygenase (5-LO) and LTA(4)-hydrolase. LTB(4) signals primarily through its G protein-coupled receptor BLT1, which is highly expressed on specific leukocyte subsets. Recent genetic studies in humans as well as knockout studies...

journal_title：Atherosclerosis

authors： Kristo F,Hardy GJ,Anderson TJ,Sinha S,Ahluwalia N,Lin AY,Passeri J,Scherrer-Crosbie M,Gerszten RE

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase...

journal_title：Atherosclerosis

authors： Thacher TN,Gambillara V,Riche F,Silacci P,Stergiopulos N,da Silva RF

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs apoptosis and associated mechanisms are still elusive. METHODS:The human EPCs we...

journal_title：Atherosclerosis

authors： Jiang H,Liang C,Liu X,Jiang Q,He Z,Wu J,Pan X,Ren Y,Fan M,Li M,Wu Z

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascu...

journal_title：Atherosclerosis

authors： Li C,Engström G,Hedblad B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

journal_title：Atherosclerosis

authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Transplant vasculopathy consists of neointima formation in graft vasculature resulting from vascular smooth muscle cell recruitment and proliferation. Variation in the severity of vasculopathy has been demonstrated. Genetic predisposition is suggested as a putative cause of this variation, although cellular m...

journal_title：Atherosclerosis

authors： Onuta G,van Ark J,Rienstra H,Boer MW,Klatter FA,Bruggeman CA,Zeebregts CJ,Rozing J,Hillebrands JL

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The plasma level of soluble CD40 ligand (sCD40L), which induces pro-inflammatory and pro-atherogenic responses, is known to be elevated in atherosclerotic patients. In this study, we investigated the mechanism of sCD40L release from human platelets, focusing on the involvement of thromboxane (TX) A(2). METHO...

journal_title：Atherosclerosis

authors： Enomoto Y,Adachi S,Matsushima-Nishiwaki R,Doi T,Niwa M,Akamatsu S,Tokuda H,Ogura S,Yoshimura S,Iwama T,Kozawa O

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. METHODS:We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-cont...

journal_title：Atherosclerosis

authors： Sattar N,Welsh P,Sarwar N,Danesh J,Di Angelantonio E,Gudnason V,Davey Smith G,Ebrahim S,Lawlor DA

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Heterozygous familial hypercholesterolemia (heFH) is a common autosomal dominant hereditary disorder caused by mutations in the LDL-receptor gene that lead to elevated plasma levels of low-density lipoprotein-cholesterol (LDL-c). Robust lowering of LDL-c levels is essential for risk reduction of premature ca...

journal_title：Atherosclerosis

authors： Pijlman AH,Huijgen R,Verhagen SN,Imholz BP,Liem AH,Kastelein JJ,Abbink EJ,Stalenhoef AF,Visseren FL

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to identify which factors influence limb salvage after bone marrow mononuclear cell implantation (BMI) in patients with chronic critical limb ischemia (CLI). METHODS:Thirteen no-option CLI patients treated with BMI were enrolled in the present study. Limb ischemia was assessed using ...

journal_title：Atherosclerosis

authors： Iso Y,Soda T,Sato T,Sato R,Kusuyama T,Omori Y,Shoji M,Koba S,Katagiri T,Kobayashi Y,Suzuki H

更新日期：2010-03-01 00:00:00

abstract：:Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed...

journal_title：Atherosclerosis

authors： Seet RC,Kasiman K,Gruber J,Tang SY,Wong MC,Chang HM,Chan YH,Halliwell B,Chen CP

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and stroke, however, the underlying mechanism remains unknown. This genomic region contains the gene encoding cyclin-dependent kinase 2A, a regulator of proliferation and different...

journal_title：Atherosclerosis

authors： Ye S,Willeit J,Xiao Q,Motterle A,Laxton RC,Oberhollenzer F,Kiechl S,Xu Q

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease. METHODS:MITICO is a multi-centered prospective observational study recruiting non-anticoagulated ischemic stroke pat...

journal_title：Atherosclerosis

authors： Blanco M,Sobrino T,Montaner J,Medrano V,Jiménez C,Masjuán J,Gómez-Escalonilla C,de Luis P,Arboix A,Castillo J,MITICO Study.

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Defects in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a highly atherogenic condition. The effect of different LDLR mutations on coronary heart disease (CHD) risk is insufficiently defined. We assessed carotid intima-media thickness (IMT), a surro...

journal_title：Atherosclerosis

authors： Junyent M,Gilabert R,Jarauta E,Núñez I,Cofán M,Civeira F,Pocoví M,Mallén M,Zambón D,Almagro F,Vega J,Tejedor D,Ros E

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:We examined the use of lipid lowering medications and control of dyslipidemia among US adults in 1999-2006. METHODS:Data were extracted from the National Health and Nutrition Examination Survey 1999-2006. RESULTS:The mean low-density lipoprotein-cholesterol (LDL-C) level significantly decreased from 3.25+/-...

journal_title：Atherosclerosis

authors： Li M,Ong KL,Tse HF,Cheung BM

更新日期：2010-02-01 00:00:00

abstract：:Apolipoprotein E (apoE) exerts prominent anti-inflammatory effects and undergoes recycling by target cells. We previously reported that the peptide Ac-hE18A-NH(2), composed of the receptor binding domain (LRKLRKRLLR) of apoE covalently linked to the Class A amphipathic peptide 18A, dramatically lowers plasma cholester...

journal_title：Atherosclerosis

authors： Datta G,White CR,Dashti N,Chaddha M,Palgunachari MN,Gupta H,Handattu SP,Garber DW,Anantharamaiah GM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with greater risk of cardiovascular events and mortality. However, in patients with peripheral arterial disease (PAD) who have severe atherosclerotic disorder or risk clustering, the major determinants of increased stiffness have been not clarified. METHODS:This st...

journal_title：Atherosclerosis

authors： Makita S,Matsui H,Naganuma Y,Abiko A,Tamada M,Nakamura M

更新日期：2010-01-01 00:00:00

abstract：:Epidemiological evidence supports the use of non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B-100 (apoB), and low-density lipoprotein particles as markers of atherogenic risk. Treatment guidelines also identify these as additional targets of lipid-modifying intervention in patients with elevated ...

journal_title：Atherosclerosis

authors： Rosenson RS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:In elderly patients traditional cardiovascular (CV) risk factors are poorly correlated with mortality and few data are available on determinants and consequences of supra-ventricular arrhythmia. In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristic...

journal_title：Atherosclerosis

authors： Vesin C,Protogerou AD,Lieber A,Safar H,Iaria P,Ducimetière P,Safar ME,Blacher J

更新日期：2009-12-01 00:00:00